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Targeting Specific PDZ Domains of PSD-95: Structural Basis for Enhanced Affinity and Enzymatic Stability of a Cyclic Peptide dayong
Title: Targeting Specific PDZ Domains of PSD-95: Structural Basis for Enhanced Affinity and Enzymatic Stability of a Cyclic Peptide dayong
Category: Recreation & Sports / Health Care
Details: Words: 3877 | Pages: 16.5 (approximately 235 words/page)
Targeting Specific PDZ Domains of PSD-95: Structural Basis for Enhanced Affinity and Enzymatic Stability of a Cyclic Peptide dayong
A cyclic peptide, Tyr-Lys-c[-Lys-Thr-Glu(βAla)-]-Val, incorporating a β-Ala lactam side chain linker and designed to target the PDZ domains of the postsynaptic density protein 95 (PSD-95), has been synthesized and structurally characterized by NMR while free and bound to the PDZ1 domain of PSD-95. While bound, the lactam linker of the peptide makes a number of unique contacts outside the canonical PDZ binding motif, providing a novel target for PDZ-domain specificity as …showed first 75 words of 3877 total…
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…showed last 75 words of 3877 total…A.M. (1994). Young Investigator Award Lecture. Structures of larger proteins, protein-ligand and protein-DNA complexes by multidimensional heteronuclear NMR. Protein Sci. 3, 372-390. [Medline]
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Received: November 21, 2003
Revised: January 8, 2004
Accepted: January 8, 2004
Published: April 16, 2004
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